I would argue that the big eyes in the Chihuahua varieties and in various other small dogs like terriers and corgis are the result of exactly the same forces brought to bear on breeding choices.
Small and cute is not the only distortion going on in mass breeding, which shows up in the funhouse mirror of shelters as abandoned dogs.
I'm too familiar with the tragedy of hip displasia. Big dog breeds suffer that one a lot, and they already have shorter lives--why is that, anyway? Plus, there's the hyuuuuge egotism (and macho fears) displayed in breeding fighting dogs. People like that messed up the collies and the German shepherds, and they were messing with Huskies and bull terriers (pit bulls) but they've moved on to bigger.
It used to be that the fantasy German shepherd owners were proud of getting perfect obedience performance out of these very powerful dogs, and put a lot of work into it. Even if nobody else could get near the dog's owner (a problem in cases where the EMTs can't leave the ambulance to help the owner), the owner had control of them.
Now the drug dealers out here cross Mastiffs and Canarias, not for dogfighting rings (where you need more agility) not even much good as watchdogs (because they aren't bonded well enough with their owners to protect them in favor of outsiders) but purely to bully/intimidate people. There's some whacked-out lazy fantasy going on now. Most of these folks just throw the dogs in a yard to keep everybody out (even themselves) because they don't work with the dogs enough to have any handler-control over them in a problem situation. They often don't feed them enough, either. It's totally cracked.